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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTK
All Species:
8.79
Human Site:
S433
Identified Species:
16.11
UniProt:
P33981
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33981
NP_003309.2
857
97072
S433
E
Q
P
V
F
S
V
S
K
Q
S
P
P
I
S
Chimpanzee
Pan troglodytes
XP_001146752
857
97034
S433
E
Q
P
V
F
S
V
S
K
Q
S
P
P
I
S
Rhesus Macaque
Macaca mulatta
XP_001111082
778
87619
A394
W
Q
S
K
R
K
S
A
C
I
N
Q
N
P
V
Dog
Lupus familis
XP_539016
855
96614
S431
E
Q
P
A
F
S
V
S
K
Q
S
P
P
I
S
Cat
Felis silvestris
Mouse
Mus musculus
P35761
856
96192
P429
R
H
V
P
D
V
T
P
K
A
D
K
E
S
P
Rat
Rattus norvegicus
NP_001101642
835
94323
D411
P
D
V
T
P
K
A
D
K
E
S
P
P
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512474
935
104827
P436
S
G
L
E
H
R
C
P
S
F
E
P
P
G
G
Chicken
Gallus gallus
XP_419867
879
99691
R437
V
M
Q
Q
N
C
Y
R
E
R
S
S
L
E
Q
Frog
Xenopus laevis
NP_001082090
882
99060
P435
T
P
R
Q
I
F
Q
P
E
M
I
F
P
A
G
Zebra Danio
Brachydanio rerio
Q8AYG3
982
109993
H495
T
L
L
L
P
A
E
H
Q
E
S
S
E
A
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002301009
818
91361
K408
N
V
K
L
E
P
S
K
P
E
N
K
E
K
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565160
777
86358
F393
N
Y
D
P
D
L
F
F
K
V
N
G
K
L
Y
Baker's Yeast
Sacchar. cerevisiae
P54199
764
86809
L380
L
Q
Q
E
N
K
R
L
K
R
S
L
D
D
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
85.7
87.4
N.A.
74.3
76.9
N.A.
64.2
61
52.8
41.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
87.7
92.6
N.A.
84.8
85.6
N.A.
73.6
74.5
68.4
57
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
93.3
N.A.
6.6
33.3
N.A.
13.3
6.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
20
93.3
N.A.
6.6
46.6
N.A.
13.3
20
13.3
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.1
N.A.
N.A.
22.9
22.7
N.A.
Protein Similarity:
40.2
N.A.
N.A.
42.3
44.5
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
20
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
8
8
0
8
0
0
0
16
8
% A
% Cys:
0
0
0
0
0
8
8
0
8
0
0
0
0
0
0
% C
% Asp:
0
8
8
0
16
0
0
8
0
0
8
0
8
8
0
% D
% Glu:
24
0
0
16
8
0
8
0
16
24
8
0
24
8
8
% E
% Phe:
0
0
0
0
24
8
8
8
0
8
0
8
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
0
8
0
8
16
% G
% His:
0
8
0
0
8
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
0
8
8
0
0
24
0
% I
% Lys:
0
0
8
8
0
24
0
8
54
0
0
16
8
8
0
% K
% Leu:
8
8
16
16
0
8
0
8
0
0
0
8
8
16
0
% L
% Met:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
16
0
0
0
16
0
0
0
0
0
24
0
8
0
0
% N
% Pro:
8
8
24
16
16
8
0
24
8
0
0
39
47
8
8
% P
% Gln:
0
39
16
16
0
0
8
0
8
24
0
8
0
0
8
% Q
% Arg:
8
0
8
0
8
8
8
8
0
16
0
0
0
0
0
% R
% Ser:
8
0
8
0
0
24
16
24
8
0
54
16
0
8
31
% S
% Thr:
16
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% T
% Val:
8
8
16
16
0
8
24
0
0
8
0
0
0
0
16
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _